Conclusions: Our findings validate the association between VO(2) and SWT distance and facilitate the

interpretation of the PARP activation test in general practice, particularly when deciding the candidacy of a patient for surgical resection. Copyright (C) 2009 S. Karger AG, Basel”
“Meningoencephalitis is a rare but aggressive complication of rheumatoid arthritis (RA). The most common complications of RA occur in the severe and chronic stages of the disease. Only a few cases have been reported in the literature. The symptoms are usually nonspecific, and arthralgia may be missing. Brain MRI and CSF analysis are useful to guide the diagnosis. However, a biopsy is required to demonstrate the existence of granulomatous lesions and the lack of mycobacterium infection. Early detection is essential to prevent neurological complications. Treatment consists MK-1775 Cell Cycle inhibitor of intravenous high doses of corticoid followed by oral tapered doses associated with immunosuppressive therapy. The present case is remarkable by the presence of granulomatous lesions in the lung and meninges and the dramatic improvement after immunosuppressive therapy.”
“Background: Glenoid replacement is challenging due to the difficult joint exposure and visualization

of anatomical reference landmarks. Improper positioning of the glenoid component or inadequate correction of the retroversion using currently

available instrumentation may lead to early failure. The objective of this Study was to evaluate a computer-assisted technique to achieve a more accurate placement of the glenoid component compared to traditional techniques.\n\nMethods: Sixteen paired cadaveric shoulders were Immunology & Inflammation inhibitor randomized to either traditional or computer-assisted glenoid implantation. Preoperative planning consisting of CT scanning with 3-dimensional image modeling of the shoulder specimens and intraoperative tracking with real-time feedback provided to the surgeon was employed in the computer-assisted group. A validated, previously published, standardized protocol for tracking the orientation of the glenoid in space using 3 glenoid surface landmarks was employed. All phases of glenoid implantation (initial guide pin insertion, reaming, drilling of the peg holes, and final component implantation) were tracked and recorded by the computer. A post-implantation CT scan was performed in both groups to compare how accurately the implants were placed.\n\nResults: The computer-assisted technique was more accurate in achieving the correct version during all phases of glenoid implantation and as measured on the post-implantation CT scan (P<.05). The largest errors with traditional glenoid implantation were observed during drilling and, more so, during reaming. The trend was to overly retrovert the glenoid.